Selank has been studied since the 1980s, principally by the Myasoedov group at the Institute of Molecular Genetics. The literature spans anxiolytic activity, GABAergic signalling, learning and memory, and immune modulation.
1Zozulya, A. A., Neznamov, G. G., Siuniakov, T. S., et al. (2008). Efficacy and possible mechanisms of action of a new peptide anxiolytic Selank in the therapy of generalized anxiety disorders and neurasthenia. Zhurnal Nevrologii i Psikhiatrii. The principal clinical trial of Selank in anxiety disorders. Search PubMed →
2Kolomin, T., Shadrina, M., Slominsky, P., Limborska, S., Myasoedov, N. (2013). A new generation of drugs: synthetic peptides based on natural regulatory peptides. Neuroscience & Medicine. Overview of the tuftsin-analogue class Selank belongs to. Search PubMed →
3Volkova, A., Shadrina, M., Kolomin, T., et al. (2016). Selank administration affects the expression of some genes involved in GABAergic neurotransmission. Frontiers in Pharmacology. Mechanistic work on the GABAergic pathway. Search PubMed →
4Filatova, E., Kasian, A., Kolomin, T., et al. (2017). GABA, selank, and olanzapine affect the expression of genes involved in GABAergic neurotransmission. Frontiers in Pharmacology. Search PubMed →
5Kasian, A., Kolomin, T., Andreeva, L., et al. (2017). Peptide Selank enhances the effect of diazepam in reducing anxiety in unpredictable chronic mild stress conditions in rats. Behavioural Neurology. Search PubMed →
6Semenova, T. P., Kozlovskaia, M. M., Zuikov, A. V., et al. (2007). Experimental analysis of the effects of Selank on learning and memory. Eksperimental'naia i Klinicheskaia Farmakologiia. Search PubMed →
7Kozlovskii, I. I., Danchev, N. D. (2003). The optimizing action of the synthetic peptide Selank on a conditioned active avoidance reflex in rats. Neuroscience and Behavioral Physiology. Search PubMed →
8Uchakina, O. N., Uchakin, P. N., Miasoedov, N. F., et al. (2008). Immunomodulatory effects of Selank in patients with anxiety-asthenic disorders. Zhurnal Nevrologii i Psikhiatrii. Search PubMed →
9Sollertinskaya, T. N., Shorokhov, M. V., Ashmarin, I. P., et al. (2008). Compensatory effects of Selank on higher nervous activity functions in primates. Zhurnal Evoliutsionnoi Biokhimii i Fiziologii. Search PubMed →
10Medvedeva, E. V., Dmitrieva, V. G., Povarova, O. V., et al. (2014). The peptide Semax affects the expression of genes related to the immune and vascular systems. Molecular Biology. Comparative context for the Myasoedov peptide series. Search PubMed →
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