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MOTS-c and NAD+ injection pen with travel case, vial and needle tips
MOTS-c and NAD+ — two compounds, one pen The pen in detail — energy at the source Morning ritual — two minutes at the counter Pre-workout — train hard, recover harder Everything you need for your first dose
Physician Reviewed
503A Compounded
Ships Cold
MOTS-c & NAD+ · Cellular Energy Pen Injectable

You're not tired. Your mitochondria are.

Doctor-formulated MOTS-c + NAD+ in a reusable injection pen — cellular fuel your body actually absorbs. No pills that never make it past digestion. No clinic drip. No stimulants.

Physician-formulated by Dr. Amy Seinfeld, D.O.
Formulation Authority · Ginspire Health LLC
A. Seinfeld
⚡
Steady energy — no stimulant crash
🧬
Mitochondrial + metabolic support
🧠
Focus and mental clarity
💉
Reusable pen · no reconstitution
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With Pen
Includes reusable pen + case
Vials Only
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Includes the reusable injection pen and travel case. Buy it once — every refill after this can be vials only.
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Physician reviewed before fulfillment. Ships cold-packed, Next Day Air. $50 flat shipping · free over $949.
⚕️
Physician Review Included

Doctor review & clearance included and is required prior to shipping. Full refund if not approved. Mon–Thu fulfillment.

  • ✓ Intake form emailed immediately after purchase
  • ✓ Third-party tested · COA available
  • ✓ 503A compounded · FDA registered facility
  • ✓ Ships cold-packed · Next Day Air · Mon–Thu
  • ✓ Pre-mixed — no reconstitution required
The Real Problem

You're not tired.
Your mitochondria are.

Every cell in your body runs on ATP, and mitochondria are what make it. They need NAD+ as the coenzyme that drives the whole process — and NAD+ declines steadily with age.

So you reach for caffeine. But a stimulant doesn't produce energy — it borrows it, masking fatigue signals while the underlying production problem stays exactly where it was. That's why the crash arrives on schedule, and why more coffee stops working.

NAD+
The coenzyme mitochondria require to produce ATP
MOTS-c
Mitochondrial-derived peptide studied for metabolic signaling
Declines
NAD+ levels fall with age
Subcutaneous
Bypasses the digestion that limits oral NAD
What Is It, Really

Two compounds. One pen.
Energy at the source.

MOTS-c is a peptide encoded inside mitochondrial DNA itself — one of a small family of mitochondrial-derived peptides discovered in 2015. It's studied for its role in metabolic signaling and how the body uses fuel, which is why researchers often describe it in the same breath as exercise adaptation.

NAD+ is a coenzyme present in every cell you have. Mitochondria depend on it to convert fuel into ATP, and it's also central to the sirtuin and DNA-repair pathways researchers associate with healthy aging. Levels decline as you get older.

Delivered together by subcutaneous pen injection, both bypass the digestive breakdown that limits oral NAD precursors — the reason capsules deliver so little of what's on the label.

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

MOTS-c and NAD+ converging into one injection pen — two compounds, one pen
Built For Six Kinds of People

Who this is really for.

Different reasons for running on empty. Same underlying bottleneck — cellular energy production.

The 3PM Crasher — the afternoon wall that a fourth coffee doesn't fix
Steady

The 3PM Crasher

Fine until mid-afternoon, then the wall. A fourth coffee doesn't fix it because caffeine was never the missing input.

  • Steadier energy across the day
  • No stimulant spike and crash
  • Supports cellular fuel production
The Athlete — recovery is the ceiling on training volume
Output

The Athlete

Training volume is capped by recovery, and recovery is capped by cellular energy. Dose in the morning before a session.

  • Supports exercise capacity
  • Everyday recovery support
  • Non-steroidal · no banned-substance flag
The 40+ Optimizer — NAD+ declines with age, restore the input
Longevity

The 40+ Optimizer

NAD+ declines with age, and so does the energy that depends on it. This is the upstream input, not another downstream fix.

  • Supports DNA repair pathways
  • Sirtuin pathway support
  • Healthy aging at the cellular level
The Executive — the last call should match the first
Clarity

The Executive

Decisions all day, and the quality of the last one should match the first. Mental clarity is downstream of cellular energy.

  • Supports focus and clarity
  • Steadier output through the day
  • Two minutes, three mornings a week
The IV Drip Convert — same input, your schedule
Convenience

The IV Drip Convert

Already sold on NAD+ — just done with the clinic appointments, the hours in a chair, and the invoice each time.

  • At-home subcutaneous pen
  • No appointments, no chair time
  • A fraction of per-visit clinic cost
The Supplement Skeptic — it wasn't the compound, it was the route
Absorption

The Supplement Skeptic

Tried oral NAD precursors and felt nothing. Reasonable — most of an oral dose is broken down before it reaches circulation.

  • Bypasses first-pass metabolism
  • Pre-mixed · no reconstitution
  • COA-verified purity
The Questions Everyone Asks

Everything you need to know.
Straight answers.

What are the benefits of MOTS-c + NAD+?+

Two of the most studied compounds for cellular energy and metabolism, delivered subcutaneously for efficient absorption.

  • Supports Cellular Energy — NAD+ is the coenzyme mitochondria rely on to produce ATP
  • Supports Metabolic Function — MOTS-c is studied for its role in metabolism and fuel use
  • Supports Mitochondrial Performance — output and resilience at the cellular level
  • Supports Healthy Aging — NAD+ supports DNA repair pathways and sirtuins
  • Supports Recovery & Stamina — may support exercise capacity and everyday recovery
  • Supports Mental Clarity — studied for focus alongside physical energy
Who should use this pen?+

Adults looking to support daily energy, metabolism, and healthy aging. Not intended for anyone under 18, or for those who are pregnant or nursing. If you have a medical condition or take prescription medication, talk with your provider before starting — and note that every order is reviewed by a physician before it ships.

How is this different from oral NAD supplements?+

Oral NAD and its precursors are largely broken down in digestion before reaching circulation. A subcutaneous injection delivers NAD+ and MOTS-c directly, avoiding first-pass metabolism entirely. It's the same reason injectable B12 is used instead of tablets in people who don't absorb well.

How should I use this pen?+

Step 1 — 5 unit test dose. Assess tolerance before going further.

Step 2 — 10 unit test dose. If the first was well tolerated.

Ongoing protocol — 15 units daily, five days on, two days off. Taken in the morning, ideally before a workout. That schedule makes one vial a 30-day supply.

Rotate injection sites and clean the site before each use. Follow your provider's direction if it differs.

Are there any side effects?+

Most people tolerate this well. Mild, short-lived effects may include a flushing or warm sensation from NAD+, temporary redness or tenderness at the injection site, or mild nausea if injected too quickly. Inject slowly — the flush is the most common report and it is dose-rate related. Contact your provider if you experience unusual or persistent symptoms.

Do I need the pen if I've ordered before?+

No. The pen is reusable — buy it once. Every reorder after that can be the vials-only option, which is why we price it separately rather than forcing you to pay for hardware you already own.

What is the physician review, and how does it work?+

Immediately after purchase you'll receive an intake form by email. A physician reviews your responses before anything ships. If you're not cleared, you receive a full refund — no charge, no product sent. Orders clear for Mon–Thu fulfillment.

How does it ship, and how do I store it?+

Cold-packed and shipped Next Day Air, Monday through Thursday, so nothing sits in a carrier facility over a weekend. Shipping is a $50 flat rate, free on orders over $949. Refrigerate on arrival. Do not freeze. Protect from light and heat.

How to Actually Use It

Administration protocol.

Two test doses, then a fixed weekly rhythm. One vial carries you a full month.

The protocol — 5 unit test dose, then 10 units, then 15 units daily, five days on and two off. One pen, one month.

Test Dose — Step 1

5 units. Your first dose. Assess tolerance before continuing.

Test Dose — Step 2

10 units. If step 1 was well tolerated, step up before beginning the protocol.

Ongoing Dose

15 units daily. Five days on, two days off.

Timing

Morning — ideally before a workout.

Site

Subcutaneous — abdomen or thigh. Rotate weekly and clean before each use.

Supply

At 15 units daily on a 5-on/2-off schedule, one vial is a 30-day supply.

Storage

Refrigerate on arrival. Do not freeze or shake. Protect from light.

Sharps

New sterile needle every injection. Dispose in a sharps container — never household trash.

⚠️ Inject slowly. NAD+ can produce a warm flushing sensation when delivered too fast. This is the most commonly reported effect, it is related to injection speed rather than dose, and it passes. Taking ten to fifteen seconds on the plunger prevents it in most people.

Follow the protocol provided by your physician after intake review. These statements have not been evaluated by the FDA.

The Experience

What to expect,
week by week.

This builds with consistent use. Here's the progression most people describe.

Days 1 to 3 — a lighter gear
Days 1–3

A Lighter Gear

A subtle lift as NAD+ and MOTS-c reach circulation. Many describe feeling more awake and noticing less afternoon drag. A warm flush on the first few doses is normal.

Week 1 to 2 — steadier through the day
Week 1–2

Steadier Through The Day

Energy holds more evenly rather than spiking and falling, and focus often sharpens as cellular fuel support builds with consistent dosing.

Week 4 to 8 — full protocol effect
Week 4–8

Full Protocol Effect

Sustained energy, metabolic support, and the cellular and mitochondrial benefits associated with NAD+ and MOTS-c over a full protocol.

Individual results may vary. These statements have not been evaluated by the FDA.

Real Value

A fraction of a clinic drip.
Without the chair time.

NAD+ IV therapy typically runs a few hundred dollars per infusion and several hours in a clinic, repeated on a schedule. This is the same category of input, delivered at home in about two minutes.

$249.75
Per vial on the 4-vial protocol
~2 min
Per dose, at home
5 on / 2 off
15 units daily, AM · one vial lasts 30 days
0
Clinic appointments required
The Comparison

Injection vs. oral NAD capsules.

Oral capsule absorption versus pen injection — it wasn't the compound, it was the route

Oral NAD+ and its precursors face a hard biological problem: the molecule is largely broken down in the digestive tract and liver before it reaches circulation. That's not a formulation flaw any brand has solved — it's first-pass metabolism doing exactly what it does.

Subcutaneous injection sidesteps the entire pathway. What's in the vial reaches the bloodstream. This is why people who felt nothing from a shelf of capsules often notice a difference here — the compound was never the issue, the delivery route was.

✗ Oral NAD Capsules

  • Degraded before circulation
  • Large daily doses to compensate
  • Unpredictable absorption
  • Ongoing monthly cost

✓ Pen Injection

  • Bypasses first-pass metabolism
  • Precise unit dosing
  • Consistent delivery
  • Pre-mixed · no reconstitution
What It Does

Six reasons clinicians
recommend MOTS-c + NAD+.

Two compounds working at the same place in the system — inside the mitochondria.

Supports Cellular Energy

NAD+ is the coenzyme mitochondria depend on to convert fuel into ATP. Supporting the input supports the output — steadier stamina rather than a borrowed spike.

Energy · ATP · Stamina

Supports Metabolic Function

MOTS-c is a mitochondrial-derived peptide studied for its role in metabolism and how the body selects and uses fuel.

Metabolism · Fuel · Balance

Supports Mitochondrial Performance

Together they support the cell's power plants for both output and resilience under load.

Cells · Power · Resilience

Supports Healthy Aging

NAD+ supports the DNA repair pathways and sirtuin activity that researchers associate with healthy aging.

Longevity · Repair · Renewal

Supports Recovery & Stamina

By supporting cellular energy production, this combination may support exercise capacity and everyday recovery between sessions.

Recovery · Output · Endurance

Supports Mental Clarity

NAD+ is studied for supporting focus and clarity alongside physical energy — the brain is metabolically expensive tissue.

Focus · Clarity · Sharpness

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

Clean Formula

Two compounds. Zero fillers.

Pre-mixed in a licensed 503A compounding pharmacy. Nothing in the vial that isn't doing a job.

MOTS-c

Mitochondrial-derived peptide

A 16-amino-acid peptide encoded within mitochondrial DNA, first described in 2015. Studied for its role in metabolic regulation and cellular fuel use — one of the few peptides that originates inside the mitochondria rather than acting on them from outside.

NAD+

Nicotinamide adenine dinucleotide

A coenzyme present in every living cell, essential to mitochondrial ATP production and central to sirtuin signaling and DNA repair pathways. Levels decline with age, which is what makes direct delivery worth doing.

Why Together?

Substrate plus signal

NAD+ supplies the coenzyme the energy pathway runs on. MOTS-c acts on the signaling side of mitochondrial and metabolic regulation. One provides the material, the other supports how it's used.

Sterile Base

Delivery

Pharmaceutical-grade sterile solution. Non-steroidal. No toxic fillers, preservatives, or parabens. Pre-mixed — no reconstitution, no guesswork.

NAD+ supplies the coenzyme, MOTS-c directs the signal — substrate and signal
The Science

How it works
inside your body.

Subcutaneous delivery, then straight to the mitochondria — no digestive detour.

MOTS-c and NAD+ injection pen technical diagram — reusable, pre-mixed, precise unit dosing, subcutaneous
01

Subcutaneous Injection

The pen places the solution into the fatty tissue just under the skin, where absorption into circulation begins. No pills, no digestion.

Bypasses first-pass metabolism
02

Direct Absorption

NAD+ and MOTS-c enter the bloodstream far more efficiently than oral NAD, which is largely degraded in the digestive tract before it can be used.

More efficient than oral
03

Mitochondrial Action

NAD+ supplies the coenzyme the electron transport chain requires to produce ATP, while MOTS-c signals within the mitochondria to support metabolic regulation and fuel use.

Coenzyme · Signaling · ATP
04

Cumulative Effect

With consistent dosing across the 5-on/2-off protocol, support accumulates. Most people describe steadier energy and sharper focus developing over four to eight weeks.

Full effect at 4–8 weeks
The Comparison

Pen vs. NAD+ IV clinic.

NAD+ IV therapy works. That's not in question. The problem is everything around it — a few hundred dollars per infusion, several hours sitting in a clinic chair, and an appointment you have to schedule and keep, repeated on a maintenance cadence indefinitely.

For most people the drip isn't abandoned because it stopped working. It's abandoned because the logistics collapse after the third or fourth visit. A protocol you can complete at home in two minutes before a workout is one you'll still be doing in month four.

✗ IV Clinic

  • Hundreds per infusion
  • Hours in a chair
  • Appointment-dependent
  • Travel each visit

✓ Pen Injection

  • Per-month cost, not per-visit
  • About two minutes
  • On your schedule
  • Reusable pen · vials-only refills
NAD+ IV clinic versus at-home pen injection — same input, your schedule
Why SeinfeldMD

Not all peptide brands
are equal.

Most suppliers prioritize volume over patients. We were built the other way around.

StandardSeinfeldMDOther Peptide Brands
Physician review required before every shipment✓✕
Pre-mixed — no reconstitution required✓✕
503A licensed compounding pharmacy✓✕
Third-party purity tested — every batch✓✕
Cold-chain shipping — Mon–Thu, Next Day Air✓✕
Reusable pen — refill without rebuying hardware✓✕
Full refund if not cleared by the physician✓✕
APA Member — verified peptide sourcing✓✕
Dr. Amy Seinfeld, D.O.
Formulation Authority · Ginspire Health LLC · Boca Raton, FL
"I review every injectable order before it ships. Not as a formality — because a compounded injectable belongs to a different category of responsibility than a supplement, and it should be treated that way."
The Comparison

Cellular fuel vs. caffeine and energy drinks.

Caffeine curve versus steady cellular energy — one masks the signal, one feeds the system

Caffeine doesn't create energy. It blocks adenosine — the molecule that accumulates through the day and tells you you're tired. The fatigue signal gets muted; the fatigue itself continues accruing underneath. When the block wears off, everything you didn't feel arrives at once.

That's the crash, and it's also why tolerance builds and the dose keeps climbing. Nothing about a stimulant addresses the production side of the equation.

MOTS-c and NAD+ operate at the other end entirely — supporting the machinery that makes ATP in the first place. Not a replacement for your morning coffee if you enjoy it. A different mechanism, doing a different job.

✗ Stimulants

  • Masks the fatigue signal
  • Tolerance climbs
  • Predictable crash
  • Can disrupt sleep

✓ MOTS-c + NAD+

  • Supports ATP production
  • No stimulant tolerance
  • No crash cycle
  • Morning dosing, no sleep impact
Important Shipping & Storage

Ships cold.
Stays cold.

Unlike our nasal sprays, injectables require true cold chain. This section is required reading.

Monday through Thursday. On purpose.

We ship injectables cold-packed via Next Day Air, Monday through Thursday. We don't ship Fridays. That's a deliberate constraint, not a limitation — it keeps your order out of a carrier facility over a weekend, where a cold pack has two unrefrigerated days to fail.

Your order ships only after physician clearance. If review lands late in the week, your package waits for Monday rather than risking a weekend in transit.

Cold-packed injectable shipping — ships cold, stays cold
1

Refrigerate immediately on arrival. Do not leave the package sitting at the door.

2

Do not freeze and do not shake. Both damage peptide integrity.

3

Protect from light and heat. Store upright, away from the fridge door.

4

Keep out of reach of children. Store needles separately in a secure place.

⚠️ WARNING: If your package arrives warm or the cold pack has fully thawed, do not use it. Contact support and we will replace the order.
Before Your First Injection

Your first dose,
step by step.

If you've never used an injection pen, this is the part that feels intimidating. It takes about two minutes, and after the first time it takes thirty seconds.

Everything you need for your first dose, laid out — pen, vial, needle tips, alcohol pads, sharps container
1

Wash Hands & Check Contents

Pen, vial, needle tips, and travel case. Confirm the solution is clear and free of particles.

2

Load the Vial

Insert the vial into the pen chamber and secure. Wipe the rubber top with an alcohol pad first.

3

Attach a New Needle

A fresh sterile needle every single injection. Remove both caps and keep the outer cap for disposal.

4

Dial Your Dose

Start at 5 units for your first test dose. Then 10 units. Then 15 units for the ongoing protocol.

5

Clean the Site & Inject

Abdomen or thigh. Alcohol pad, insert at a slight angle, press slowly until the dial reads zero, hold five seconds.

6

Recap & Dispose Safely

Remove the needle, place it in a sharps container, recap the pen, and return it to the refrigerator.

Take ten to fifteen seconds on the plunger. Injecting quickly is the main cause of the NAD+ flush — going slowly prevents it for most people.
Verified & Trusted

Memberships & affiliations.

American Peptide Association member
✓ Official Member

American Peptide Association

The leading industry body advancing the science, safety, and standards of peptide research.

Seeds Scientific Research & Performance Institute member
✓ Official Member

Seeds Scientific Research & Performance Institute

A physician-led institute advancing the clinical standards of peptide therapy and cellular medicine.

The Studies

Peer-reviewed references.

MOTS-c was first described in 2015. NAD+ biology has been studied for decades.

1
Lee, C., Zeng, J., Drew, B. G., et al. (2015). The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metabolism. Original MOTS-c identification paper. View study →
2
Reynolds, J. C., Lai, R. W., Woodhead, J. S. T., et al. (2021). MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nature Communications. View study →
3
Kim, K. H., Son, J. M., Benayoun, B. A., Lee, C. (2018). The mitochondrial-encoded peptide MOTS-c translocates to the nucleus to regulate nuclear gene expression. Cell Metabolism. View study →
4
Lu, H., Wei, M., Zhai, Y., et al. (2019). MOTS-c peptide regulates adipose homeostasis to prevent ovariectomy-induced metabolic dysfunction. Journal of Molecular Medicine. View study →
5
Verdin, E. (2015). NAD+ in aging, metabolism, and neurodegeneration. Science. Review of NAD+ decline and its metabolic consequences. View study →
6
Rajman, L., Chwalek, K., Sinclair, D. A. (2018). Therapeutic potential of NAD-boosting molecules: the in vivo evidence. Cell Metabolism. View study →
7
Cantó, C., Menzies, K. J., Auwerx, J. (2015). NAD+ metabolism and the control of energy homeostasis: a balancing act between mitochondria and the nucleus. Cell Metabolism. View study →
8
Imai, S., Guarente, L. (2014). NAD+ and sirtuins in aging and disease. Trends in Cell Biology. View study →
9
Yoshino, J., Baur, J. A., Imai, S. (2018). NAD+ intermediates: the biology and therapeutic potential of NMN and NR. Cell Metabolism. View study →
10
Covarrubias, A. J., Perrone, R., Grozio, A., Verdin, E. (2021). NAD+ metabolism and its roles in cellular processes during ageing. Nature Reviews Molecular Cell Biology. View study →

Statements on this website have not been evaluated by the Food and Drug Administration (FDA). Products offered are intended for general wellness purposes only and are not intended to diagnose, treat, cure, or prevent any disease. Injectable products require physician review and clearance prior to fulfillment. If not approved, you will receive a full refund.

MOTS-c & NAD+ Pen
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