Reclaim your nights. Sleep like you used to.
Doctor-formulated Delta Sleep-Inducing Peptide spray for sleep that actually restores you — without melatonin hangovers, sedatives, or dependency.
Watch the story.
Two short videos. Adam Ginsberg on what DSIP is. And a quick overview of how it works.
One peptide. Deep, restorative sleep.
Without the hangover.
Drift into deep, restorative sleep with DSIP Nighttime Relaxation Nasal Spray — a science-backed, physician-formulated peptide designed to calm the mind and relax the body. Delta Sleep-Inducing Peptide (DSIP) supports your natural sleep cycle without sedation, dependency, or morning grogginess.
Built for consistent nightly use, DSIP works upstream — lowering cortisol at the HPA axis so your body can enter the deep, slow-wave sleep it already knows how to produce. Ideal for anyone lying awake at 11 PM, waking at 3 AM, or waking exhausted despite eight hours in bed.
DSIP promotes deeper slow-wave sleep — the stage where physical recovery, hormone regulation, and memory consolidation occur. Unlike sedatives that suppress sleep architecture, DSIP enhances its natural depth and quality without blunting REM cycles.
These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
Who this is really for.
DSIP isn't a niche product. It's a sleep tool that fixes the underlying problem — elevated cortisol at bedtime. Different people, different reasons for lying awake, same solution: deep, restorative sleep without sedation or dependency.
The Student
Because memory consolidates during deep sleep. Cramming until 2 AM doesn't help if your brain never gets slow-wave rest — you forget what you crammed.
- Deep sleep for memory consolidation
- No next-day grogginess before exams
- Reset a wrecked sleep schedule
The Business Owner
For the mind that won't shut off at 11 PM. Cortisol was designed to help you outrun a lion — not to loop through tomorrow's meeting at 2 AM.
- Downshift a mind that won't stop
- Recover overnight from decision fatigue
- Wake up ready to lead again
The Athlete
Sleep is where the actual training adaptation happens. Deep sleep = growth hormone release, muscle repair, glycogen restoration. Skip it and tomorrow's session is compromised before you start.
- Overnight recovery + tissue repair
- Deep sleep for growth hormone release
- No banned substance flag
The Creative
For the 2 AM ideas that won't stop. Your best work needs deep sleep to consolidate — but your brain thinks midnight is prime time for problem-solving.
- Wind down a racing creative mind
- Consolidate the day's work overnight
- Wake up with actual clarity, not fog
The Executive
Elevated nighttime cortisol is the executive tax. You lead all day, then can't sleep at night — because the stress response never got the memo the day ended.
- Lower cortisol before bed
- Consistent deep sleep despite pressure
- Recover for tomorrow's hard calls
The 40+ Optimizer
Sleep architecture naturally declines after 40 — less deep sleep, more nighttime wakings, more time to fall back asleep. Cortisol rhythms shift too.
- Restore age-related deep sleep loss
- Support natural circadian rhythm
- Recover growth hormone released in deep sleep
Everything you need to know.
Straight answers.
DSIP is a naturally occurring peptide that promotes deep, restorative sleep without sedation or dependency. It works with your body's own rhythms rather than overriding them — lowering cortisol at the HPA axis and enhancing slow-wave sleep.
- Supports Sleep Quality — supports deep, restorative slow-wave sleep
- Supports Stress Resilience — supports healthy cortisol levels and HPA axis regulation
- Supports Hormone Balance — may help normalize stress-related hormone activity
- Supports Recovery — supports muscle and tissue repair during rest
- Supports Mood & Focus — through higher-quality sleep, better daytime clarity
- Supports Cognitive Resilience — supports cognitive resilience and healthy oxidative balance
Anyone experiencing poor sleep quality, difficulty falling asleep, stress-related insomnia, or disrupted sleep cycles. It's particularly well-suited for individuals who want to improve their sleep naturally — without relying on melatonin, sedatives, or habit-forming sleep aids.
Melatonin signals your body that it's dark outside. Sedatives suppress your nervous system. DSIP does neither — it works upstream at the HPA axis, lowering cortisol so your body can enter the deep, slow-wave sleep it already knows how to produce. No rebound insomnia. No morning grogginess. No dependency.
Yes. SeinfeldMD DSIP Nasal Spray is non-steroidal and contains no toxic fillers or preservatives. Each batch is prepared in our SQF-certified, FDA-registered 503A compounding facility under the oversight of Dr. Amy Seinfeld, D.O. Third-party purity tested every batch.
Administer 1 spray into each nostril approximately 30 to 60 minutes before bedtime. Lay down immediately after administration to enhance absorption. May be used up to twice nightly — max 4 total sprays per 24-hour period. Consistent nightly use produces the best long-term sleep regulation.
Generally well tolerated. Mild side effects may include temporary nasal irritation or dryness, vivid dreams during the first few nights as sleep cycles adjust, mild drowsiness if taken too early, or rarely a mild headache. These typically resolve within a few nights.
No — nasal sprays no longer ship cold. Our proprietary CryoBuffer™ + Filtraphorix™ stabilization technology keeps peptides stable at any shipping temperature. However, once you receive your spray, you MUST refrigerate it immediately after attaching the spray top — this extends shelf life from 28 days to 120 days. See our shipping & storage section below for details.
Administration protocol.
Dosage
1 spray per nostril at night. Up to twice nightly — max 4 sprays per 24 hours.
Timing
30 to 60 minutes before bedtime. Lay down immediately after to enhance absorption.
Frequency
Use nightly as directed. Consistent nightly use produces the best long-term sleep regulation.
Nightly
Use every night — no cycling needed. Consistency produces the best sleep architecture results.
Duration
Use for 4 to 8 weeks or ongoing, as directed by your healthcare provider.
Storage
Refrigerate immediately on receipt. Do not freeze. Protect from light.
Ensure nasal passages are clear before spraying to maximize absorption. These statements have not been evaluated by the FDA.
What to expect,
night by night.
DSIP builds with consistent nightly use. Here's the progression most people describe.
Easier Wind-Down
A calmer transition to sleep within the first few nights. Many notice they fall asleep more easily and the mind feels quieter at bedtime. Vivid dreams are common in this phase — normal and temporary.
Deeper, Steadier Sleep
Sleep feels deeper and less interrupted. Mornings start to feel clearer — rested rather than groggy — and daytime mood feels more stable.
Full Circadian Reset
With nightly use, your sleep-wake rhythm recalibrates. Sustained deep sleep, improved recovery, and steady daytime energy build over the full protocol.
Individual results may vary. These statements have not been evaluated by the FDA.
Cheaper than sleep meds.
Actually restorative.
The average American spends $60/month on sleep aids — melatonin, ZzzQuil, sleep gummies, prescription refills. All of them either signal bedtime, sedate you, or knock you out. None of them restore sleep architecture. DSIP works out to about $1.50/day on a 3-pack.
Melatonin masks the problem. Sedatives override your nervous system. DSIP works upstream at the HPA axis — lowering cortisol and letting your body enter the deep sleep it already knows how to produce. One is a band-aid. The other is infrastructure.
Why our delivery works.
Not all peptide sprays are equal. Filtraphorix™ + CryoBuffer™ is what makes DSIP work faster, cleaner, and more consistently than any oral or under-the-tongue sleep peptide.
DSIP vs. melatonin.
Melatonin isn't actually sleep — it's a signal that tells your brain the sun has gone down. That helps when your timing is off (jet lag, shift work), but it does nothing for the cortisol and stress that keep most people staring at the ceiling. Typical doses (3–10mg) also flood your system with 10 to 30× more melatonin than your body would ever produce naturally.
DSIP works further upstream. Instead of overriding your clock, it lowers cortisol at the HPA axis and enhances the deep, slow-wave sleep your body already produces. Users describe it as less "knocked out" and more "finally able to fall and stay asleep" — without the morning grogginess or the tolerance that builds with nightly melatonin.
They work differently. Melatonin shifts your sleep timing; DSIP supports the depth and quality of sleep by calming the stress response — which is why people who feel "immune" to melatonin often notice DSIP.
It's formulated to avoid the morning fog. DSIP enhances natural slow-wave sleep rather than sedating you, so most users report waking clearer, not heavier.
Many customers switch from melatonin to DSIP. If you take prescription medication or have a medical condition, check with your provider first.
Six reasons clinicians
recommend DSIP.
Delta Sleep-Inducing Peptide has been studied since the 1970s — for sleep architecture, cortisol regulation, stress modulation, and neuroprotection — delivered via nasal spray for maximum bioavailability.
Promotes Deep, Restorative Sleep
Enhances slow-wave sleep — the stage where physical recovery, hormone regulation, and memory consolidation occur. You wake actually rested.
Supports Stress Resilience
Supports healthy cortisol levels and a calm nervous system response — helping mind and body transition into a restful state without sedatives or dependency.
Supports Hormone Balance
May help normalize stress-related hormone activity, including cortisol and growth hormone regulation — supporting overall endocrine balance during sleep cycles.
Supports Recovery
Supports muscle and tissue repair during rest — particularly valuable for active individuals, athletes, and anyone who needs their body to recover effectively overnight.
Supports Mood & Focus
Supports daytime alertness and mental clarity through better-quality sleep — because when your nights improve, your days follow. Sharper focus, steadier mood.
Neuroprotective Support
Supports healthy oxidative balance and cognitive resilience — supporting neuronal health during the critical repair and consolidation processes of deep sleep.
One peptide. Zero fillers.
Every ingredient serves a purpose — no melatonin, no sedatives, no sugar, no proprietary blends. A single well-researched peptide at the clinically studied dose, in a clean Filtraphorix™ delivery matrix.
A 9-amino-acid peptide first isolated in the 1970s by Schoenenberger and Monnier in Switzerland. Named for its ability to induce delta-wave (slow-wave) sleep. DSIP lowers cortisol at the HPA axis, reduces ACTH secretion, and enhances the depth and quality of slow-wave sleep — without sedating or overriding your natural sleep architecture.
Unlike our Clarity & Focus blend that combines Semax + Selank, DSIP is a single-peptide formulation. DSIP acts directly on the cortisol-sleep axis — combining it with other peptides would dilute the mechanism. Sleep restoration is best achieved by targeting the actual cause.
Enhances nasal absorption and formula stability. Part of the Filtraphorix™ delivery system that ensures maximum bioavailability through the nasal mucosa.
Opens nasal passages for optimal peptide delivery. Natural, clean, no synthetic decongestants.
Other ingredients: sterile phosphate-buffered saline, glycerin. 90 sprays per bottle — 100mcg per serving.
How it works
inside your body.
Nasal delivery bypasses the digestive system entirely — active compounds reach the bloodstream faster and more completely than any capsule or oral drop.
Nasal Administration
1 spray per nostril. Nasal mucosa immediately begins absorbing peptides, bypassing digestion and first-pass liver metabolism entirely.
Rapid Bloodstream Absorption
Peptides enter the bloodstream directly through the nasal mucosa within minutes. Some absorbed via olfactory pathways for near-direct CNS access.
Cortisol Reduction & HPA Axis
DSIP lowers cortisol at the HPA axis and reduces ACTH secretion. Your nervous system downshifts, letting your body enter the deep sleep it already knows how to produce.
Cumulative Effect
With consistent use over 4 to 8 weeks, peptide concentrations build to therapeutic levels. Most notice initial effects within 1 to 2 weeks.
Sleep pills lose 70–90% potency.
Sprays don't.
Oral sleep supplements pass through your digestive system and liver — destroying most of the active compound before it reaches your bloodstream. And if you fall asleep before it kicks in, you wasted the dose. Filtraphorix™ nasal delivery bypasses all of that.
✗ Sleep Pills & Gummies
- 10–30% bioavailability
- 45–90 min to take effect
- Degraded by stomach acid
- Loaded with sugar or fillers
- Melatonin overdose (3–10mg)
✓ DSIP Nasal Spray
- Near-100% bioavailability
- 60-second absorption
- Bypasses digestion entirely
- Precise 100mcg dosing
- Single mechanism, single dose
DSIP vs. sleep gummies.
Most "sleep gummies" are melatonin in candy form — usually 3–10mg, plus sugar, syrups, gelatin, and coloring. Beyond the additives, the format itself works against you: anything you chew and swallow has to survive your stomach and liver (first-pass metabolism) before a fraction of it reaches your bloodstream. Slower, blunted, less predictable — and a dessert right before bed.
DSIP skips all of that. Delivered as a nasal spray, it's absorbed directly through the nasal mucosa into the bloodstream — faster onset, no sugar, no fillers, no chewing. You're getting a precisely dosed peptide prepared in a licensed compounding pharmacy, not a confection engineered to taste good.
Not necessarily — but most are melatonin plus added sugar and fillers, often at a higher dose than you need. DSIP contains no sugar or fillers and uses a different mechanism entirely.
Nasal delivery bypasses digestion, so absorption is faster and more complete than a gummy that must pass through the gut and liver first.
No. Most gummies rely on melatonin to signal bedtime. DSIP supports deeper sleep by calming the stress response and enhancing slow-wave sleep.
Not all peptide brands
are equal.
Most peptide suppliers prioritize volume over patients. SeinfeldMD was built differently — by a physician, for real clinical outcomes.
| Standard | SeinfeldMD | Other Peptide Brands |
|---|---|---|
| Physician-supervised formulation | ✓ | ✕ |
| Pre-mixed nasal spray — no reconstitution | ✓ | ✕ |
| SQF Certified & FDA Registered | ✓ | ✕ |
| Third-party purity tested — every batch | ✓ | ✕ |
| Pharmaceutical-grade (503A compounded) | ✓ | ✕ |
| Filtraphorix™ + CryoBuffer™ technology | ✓ | ✕ |
| APA Member — verified peptide sourcing | ✓ | ✕ |
"I formulated DSIP for people who want to sleep without sedating themselves or building dependency. It works at the mechanism most sleep aids ignore — the cortisol-HPA axis — and Filtraphorix™ nasal delivery makes it work in about 60 seconds."
DSIP vs.
prescription sleep aids.
Prescription sleep medications — benzodiazepines and "Z-drugs" like zolpidem — work by suppressing your central nervous system. They can knock you out, but they also blunt your natural sleep architecture, and they carry real trade-offs: next-day impairment, tolerance that builds over time, dependency, and rebound insomnia when you stop.
DSIP takes the opposite approach. Rather than forcing sleep through sedation, it works with your body — lowering cortisol and supporting the transition into the deep sleep stages you're already capable of. No sedation hangover, no habit formation, no rebound. Real rest without the baggage of a prescription sedative.
No. Sedatives suppress your nervous system to force sleep. DSIP supports your body's own ability to reach deep sleep, without sedation.
DSIP is non-habit-forming with no known rebound insomnia, and is designed for consistent nightly use without dependency.
That's a decision for you and your physician. Many people use DSIP as a natural alternative — but never stop a prescribed medication without medical guidance.
These statements have not been evaluated by the FDA. Consult your healthcare provider before changing any prescribed medication.
One peptide. Verified purity.
Every batch.
Every batch of DSIP is independently tested. Certificate of Analysis confirms purity, identity, and potency — signed by their Medical Director.
Ships warm.
Store cold.
Here's something no one else can do: our peptides now ship at any temperature, no cold packs needed — thanks to proprietary CryoBuffer™ + Filtraphorix™ stabilization technology. But once your spray arrives, you MUST refrigerate it immediately. This section is required reading.
Ships Warm, Arrives Potent.
Ginspire Health peptides use advanced stabilization technology. Previously these medications required cold-chain shipping (refrigerated transport). Now, thanks to CryoBuffer™ molecular stabilization + Filtraphorix™ delivery matrix, they arrive safely regardless of temperature — without any loss of potency or effectiveness.
As Soon As It Arrives — 2 Steps.
| Storage Condition | Shelf Life | |
|---|---|---|
| ❄️ | Refrigerated | 120 days |
| 🌡️ | Room Temperature (NOT refrigerated) |
28 days |
60 seconds to assemble.
Your spray ships in two parts to preserve stability. Take a minute to assemble before first use — then refrigerate immediately.
Check Your Package Contents
Your spray ships in two parts: the bottle and the pump mechanism. Both are inside the box. Do not discard anything until you've located both pieces.
Remove the Protective Cap From the Pump
Locate the pump inside the box. Remove the small protective cap covering the nozzle tip — you'll reuse it to seal the spray between doses.
Attach the Pump to the Bottle
Insert the pump stem into the top of the bottle and press down firmly until it clicks into place and sits flush with the bottle neck.
Prime Before First Use
Hold the bottle upright and depress the pump 3–5 times until a fine mist appears. This purges air from the stem.
Refrigerate Immediately
After first-use assembly, place the bottle in the refrigerator. Store upright, away from strong odors. Do not freeze.
Real people.
Real results.
4.9-star average from 32 verified purchases. Reviews collected through third-party verification — every reviewer is a confirmed customer.
"I am 48 and had been relying on melatonin for years with diminishing returns. DSIP is a different experience entirely. I fall asleep naturally instead of feeling sedated, and I wake up clear-headed rather than groggy."
"The knock-on effects are what sold me. Better sleep meant better recovery from training, steadier energy through the afternoon, and a noticeably better mood by week three. I did not realize how much bad sleep was costing me until it was fixed."
"I was skeptical that a nasal spray could do much for sleep, but my Oura data tells the story. Deep sleep is up almost forty minutes a night on average compared to before I started."
Memberships & affiliations.
We hold ourselves to the standards set by the bodies advancing peptide science.
American Peptide Association
The leading industry body advancing the science, safety, and standards of peptide research. Membership reflects our commitment to purity, transparency, and responsible sourcing.
Seeds Scientific Research & Performance Institute
A physician-led institute advancing the clinical standards of peptide therapy and cellular medicine.
Peer-reviewed references.
DSIP has been studied since the 1970s. The formulation behind this spray is grounded in peer-reviewed clinical research spanning sleep architecture, cortisol reduction, and neuroprotection.
Statements on this website have not been evaluated by the Food and Drug Administration (FDA). Products offered are intended for general wellness purposes only and are not intended to diagnose, treat, cure, or prevent any disease.